Harlan Teklad动物饲料Custom diet ingredients

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Diet ingredients

Custom diet ingredients

You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.

 

Our ingredients

We offer several ingredients for individual sale so that you can develop your own blends.

 

“VFT” casein

  • “Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
  • The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

  • The common vitamin mixes shown below use sucrose or corn starch as a carrier
  • Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
  • Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
  • For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
  • Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
  • Minimum order is 500 g for both stock and custom vitamin mixes
  • Our available vitamin mixes are commonly used in diets, and are available from stock
  • Vitamin mixes are shipped within a few days of order

 

Our Formula examples

 

Mineral mixes

  • The common mineral mixes shown below as examples use sucrose as a carrier
  • Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
  • Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
  • For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
  • Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
  • These mineral mixes are commonly used in diets, and are available from stock
  • Our mineral mixes are shipped within a few days of order

 

Formula examples:

 

Other mixes (may or may not be available from stock):

  • TD.83171      Vitamin mix without A, D, E, choline
  • TD.81062      Iron deficient mineral mix based on AIN-76A
  • TD.79055      Calcium and phosphorus deficient mineral mixed based on AIN-76
  • TD.98057      Calcium and phosphorus deficient mineral mixed based on AIN-93
  • CA.170760    Rogers-Harper mineral mix

Harlan Teklad动物饲料Vitamin adjusted diets

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Vitamin adjusted diets

Vitamin adjusted diets

A few vitamin adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the vitamin profile of a diet, and please read below to learn more.

Formula Examples:

Most vitamin deficient diets use vitamin-free test casein (VFT casein) as the protein source. VFT casein is casein that has been extracted with denatured alcohol to reduce the fat content from about 1% to 0.1%. In the process the content of a number of vitamins (present at low or trace levels in casein) is further reduced, making this an ideal protein source for these types of diets. Envigo produces our own VFT in-house, and we also offer this as an ingredient for those mixing their own diets.

From this vitamin deficient base, various levels of vitamins can be added back. Many formulas adjust multiple vitamins, and other nutrients.

If use of an intact protein source is not advisable, an amino acid defined diet can be used.

Contact us for other formula examples or to discuss your specific needs.

Harlan Teklad动物饲料Our work with animals

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Our work with animals

Our work with animals

Envigo is a global company that is committed to helping customers realize the full potential of their products and research which contribute to enhancing the lives of people and animals, as well as protecting the environment. The value of animals in this critical research is essential for advancing our understanding of the body in health and disease and for developing new medicines and other compounds. Without animal research, we would not be able to produce the life-changing medicines that enhance and save lives across the world.

  • Animal welfare statement
  • Concordat on openness
  • European Directive 2010-63-EU
  • Animal research links

Envigo only works with animals in research when there is no alternative method available or where research is mandated by legal or regulatory requirements. Animal research is currently mandated to:

  • Demonstrate the safety and efficacy of new medicines, for people and animals
  • Evaluate the safety of chemicals to humans, animals and the environment

In carrying out animal research for our customers at Envigo we follow the principles of the 3Rs – Replacement, Reduction and Refinement. We ensure the 3Rs are considered at all levels of the company. This means we work with alternatives to animals whenever we can, we aim to carry out studies with the fewest number of animals possible, and we take measures to minimize any pain or distress before, during, and after experimental procedures.

As well as research on animals, we use a range of other approaches and methods for research such as cell cultures, in vitro techniques, computer modelling, bioinformatics, high-throughput screening and clinical trials in people. We only work with animals when there is no other way of performing that research; in fact, legislation in many countries state that animal research is not permitted if an alternative non-animal method is available. In addition, we are working to develop alternative techniques that replace and reduce our need to work with animals in research.

At Envigo, animal welfare is a top priority. We adopt a humane and compassionate approach, actively fostering a culture of care toward our animals and aiming to operate at the highest professional standards. Animals that are well cared for allow us to produce better science and more reliable data. We have a company-wide animal welfare policy that defines and drives the standards for our animal care and welfare throughout Envigo.

Harlan Teklad动物饲料Fat/lipid adjusted

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Fat/lipid adjusted

Fat/lipid adjusted

There are numerous possibilities in adjusting both the level and source of fat in a diet. If your primary interest is inducing atherosclerosis or obesity, additional information can be found on our Teklad atherogenic and diet induced obesity (DIO) diet pages. Depending on your research goals and level of desired fat supplementation, fats can be added to a standard natural ingredient diet or a purified diet.

Purified ingredients are refined to the point of chemical simplicity and allow for extreme fat levels such as no fat diet TD.03314 or very high fat ketogenic diet TD.96355 . Unless adjustments are made to the level of fiber, diets with high fat levels will have a greater caloric density since fat contains 9 kcal/g versus 4 kcal/g for carbohydrate or protein. Animals are good at regulating caloric intake, therefore it is common to adjust other nutrients (vitamins, minerals, protein) relative to energy content to account for differences in feed intake.

Specific fats can be utilized as in this essential fatty acid deficient diet TD.84224 or to provide high levels of omega-3 polyunsaturated fat from flaxseed or fish oil. Normally, 1-2% fat from plant sources like corn or soybean oil will supply sufficient levels of essential fatty acids. Additional fat provides energy and can influence palatability due to effects on taste and texture of the diet.

Mixtures of fats can be used to mimic a Western or Mediterranean diet fatty acid profile. Contact us for a table comparing the fatty acid composition of several stocked fat sources (solid fats, oils).

We also commonly work with customer supplied oils and purified fatty acids such as DHA and EPA. If you prefer to mix fat sources in your lab, ask about a basal mix. Basal mixes are supplied in powder form and often allow you to use one diet mix for creating several different diets.

If fat stability is a concern, contact a nutritionist to discuss options for diet drying, vacuum packaging, and synthetic antioxidant supplementation.

Example diets mentioned above

 

Contact us to discuss the use of these example diets or one that better meets your needs.

Harlan Teklad动物饲料Atherogenic

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Atherogenic

Atherogenic

Diet can be a useful tool to induce or accelerate atherosclerosis in laboratory animal models. Key dietary features used to induce atherosclerosis in rodents vary depending on the research model, desired endpoint, and length of feeding. While formulations of atherogenic diets continue to evolve, the options that are well-described in the literature are summarized below. For more information on each diet option and literature references see the expandable tabs following the diet table.

 

Research use Key dietary features Examples
“Western” purified atherogenic diet
Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.

Used for diet induced obesity in a variety of rodent models.

  • High fat diet (20 – 23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)
TD.88137
TD.10885
“Western” purified atherogenic diet with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

  • High fat diet (15 – 20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate Source (0.5%)*
TD.02028
TD.09237
Hybrid high fat diets with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.

  • 75% rodent breeder diet; 25% purified ingredients
  • High fat (~15% by weight; 37% kcal from fat)
  • Saturated fatty acids (SFA >45% of total fatty acids)
  • Cholesterol (1.25%)
  • Cholate source (0.5%)*
TD.88051
TD.90221
Standard diets with added cholesterol
Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity.
  • Standard, grain-based rodent diet
  • Minimal/moderate phytoestrogen diets recommended
  • Cholesterol (1 – 4%)
TD.120097
TD.07841
TD.01383

 

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.

“Western” purified atherogenic diet

“Western” style diets are fed to genetically-modified cardiovascular models, such as Apoe and Ldlr deficient mice, to accelerate and enhance hypercholesterolemia and plaque formation and to elicit phenotypes commonly associated with metabolic syndrome. Within the atherogenic literature, a “Western” diet typically is described as a purified rodent diet with 20-23% milkfat/butterfat, 0.2% total cholesterol, and 34% sucrose by weight. TD.88137  is an example of a “Western” style diet that was originally designed to characterize and enhance atherosclerosis development in a newly generated Apoe-deficient mouse model. Contact us for more information about “Western” style diets, modifications, or possible control diets.

Examples:

  • TD.88137     Adjusted calories diet (42% from fat, 0.2% total cholesterol)
  • TD.10885   45% fat Kcal diet (0.2% total cholesterol)

Research use:

Accelerated hypercholesterolemia and plaque formation in genetically-modified models, such as Apoe and Ldlr deficient mice.

Used for diet-induced obesity in a variety of rodent models.

Key dietary features:

  • High Fat Diet (20-23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)

References:

  1. Febbraio, M., et al., Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest, 2000. 105(8): p. 1049-56.
  2. Huszar, D., et al., Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
  3. Nakashima, Y., et al., ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994. 14(1): p. 133-40.
  4. Nakashima, Y., et al., Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol, 1998. 18(5): p. 842-51.
  5. Plump, A.S., et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
  6. Towler, D.A., et al., Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem, 1998. 273(46): p. 30427-34.
  7. Tsuchiya, K., et al., FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.

“Western” purified atherogenic diet with added cholesterol and cholate source*

Wild type mice and rats generally are resistant to atherosclerosis, requiring more extreme dietary manipulation to modify lipoprotein profiles and develop mild atherosclerosis (foam cells, fatty streaks). Modern formulations are made completely of purified ingredients because this more refined approach has been reported to decrease the incidence of gallstones and liver damage associated with less refined and more traditional dietary approaches. To induce mild atherosclerosis in wild type animals, the “Western” purified diet can be modified to increase cholesterol (1-1.25%) and add a bile salt such as sodium cholate or cholic acid. Contact us for more information, modifications, or possible control diets.

Examples of purified high fat diets with added cholesterol and cholate source*:

    • TD.02028 21% milkfat (1.25% cholesterol, 0.5% cholic acid)

    • TD.09237    15% milkfat diet (1% cholesterol, 0.5% sodium cholate)

Examples of purified high fat diets with added cholesterol (without cholate source):

  • TD.96121     21% milkfat (1.25% cholesterol)

Research Use:

Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.

Will not promote obesity.

Key dietary features:

  • High fat diet (15-20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate source (0.5%)*

References:

  1. Bernal, C., et al., Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis. J Nutr Biochem, 2013. 24(11): p. 1870-81.

  2. Gao, Q., et al., Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase. Inflamm Bowel Dis, 2010. 16(12): p. 2043-54.

  3. Lichtman, A.H., et al., Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol, 1999. 19(8): p. 1938-44.

  4. Marcondes, M.C., et al., Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta. Brain Behav Immun, 2011. 25(8): p. 1649-57.

  5. Nishina, P.M., et al., Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice. J Lipid Res, 1993. 34(8): p. 1413-22.

  6. Nishina, P.M., et al., Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids, 1993. 28(7): p. 599-605.

  7. Yue, P., et al., Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice. PLoS One, 2010. 5(3): p. e9906.

  8. Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69.

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available. See TD.96121 for a purified diet and TD.94059 for a hybrid diet. Contact us for additional options.

Hybrid high fat diets with added cholesterol and cholate source*

Beverly Paigen and colleagues first characterized atherosclerosis development in C57BL/6 mice by feeding a hybrid atherogenic diet. The hybrid diet was created by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate; referred to as Thomas-Hartroft diet). The resulting mixture recreated in TD.88051 /TD.90221 (same formula) contains ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate. This group later compared the hybrid atherogenic diet approach to the more modern “western” purified atherogenic diet with added cholesterol and cholate and found that the hybrid atherogenic diet induced more gallstones and liver damage. Hybrid diets contain a variety of unrefined ingredients that may modify lipid metabolism and atherogenesis and do not allow for precise control of ingredients and nutrients for the study of chronic diseases. Although more refined diets have been developed, hybrid atherogenic diets are still popular for inducing mild atherosclerosis and gallstones in wild type mice and rats. Contact us for more information, modifications, or possible control diets.

Examples of hybrid high-fat diets with added cholesterol and cholate source*:

  • TD.88051 and TD.90221 (same formula) are Teklad product codes for hybrid atherogenic diets

Example of hybrid high-fat diet with added cholesterol (without cholate source):

Research Use:

Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) primarily in wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.

Key dietary features:

    • 75% rodent breeder diet; 25% purified ingredients

    • High fat (~15% by weight; 37% kcal from fat)

    • Saturated fatty acids (SFA >45% of total fatty acids)

    • Cholesterol (1.25%)

    • Cholate source (0.5%)*

References:

  1. Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69.

  2. Clee, S.M., et al., Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J Lipid Res, 2000. 41(4): p. 521-31.

  3. George, J., et al., Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. Arterioscler Thromb Vasc Biol, 1999. 19(3): p. 505-10.

  4. Miyake, J.H., et al., Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler Thromb Vasc Biol, 2002. 22(1): p. 121-6.

  5. Paigen, B., et al., Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis, 1987. 68(3): p. 231-40.

  6. Schreyer, S.A., D.L. Wilson, and R.C. LeBoeuf, C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis, 1998. 136(1): p. 17-24.

  7. Vergnes, L., et al., Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem, 2003. 278(44): p. 42774-84.

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available. See TD.96121 for a purified diet and TD.94059 for a hybrid diet. Contact us for additional options.

Standard diets with added cholesterol

Standard, natural ingredient diets with cholesterol added are fed to induce hypercholesterolemia. Various levels of cholesterol, fat, and/or bile salts can be added to one of the numerous standard rodent diets stocked by Envigo Teklad. For many applications, adding these components to Envigo’s minimal-to-moderate phytoestrogen global rodent diets is recommended. Our minimal phytoestrogen global rodent diets are soybean meal free, limiting the effect of phytoestrogens on your research outcomes. Soybean meal, a common dietary source of phytoestrogens, has been shown to decrease aortic fatty streak development and modify plasma cholesterol, which may reduce the risk of developing atherosclerosis. Limiting dietary soybean meal may reduce confounding variables within your dietary-induced atherosclerosis model. Contact a nutritionist to discuss additional diet options.

Examples of minimal and moderate phytoestrogen rodent diets with added cholesterol:

    • TD.120097   1% cholesterol diet (2020 – minimal phytoestrogens)

    • TD.07841     2% cholesterol diet (2016 – minimal phytoestrogens)

    • TD.01383     2% cholesterol (2018 – Moderate phytoestrogens)

Research use:

Induce hypercholesterolemia in genetically-modified and wild type models without promoting obesity.

Key dietary features:

    • Standard, grain-based rodent diet

    • Minimal/moderate phytoestrogen diets recommended

    • Cholesterol (1 – 4%)

References:

  1. Belch, J.J., et al., Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo. Microvasc Res, 2013. 85: p. 86-92.
  2. Hartvigsen, K., et al., A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 878-85.

Diets for additional animal models of atherosclerosis

Rabbits, hamsters, and swine are common models of atherosclerosis. Contact a nutritionist for information and formula examples. See rabbit, swine and other species for information and formula examples.

For additional phytoestrogen information, see our list of phytoestrogen references.

Harlan Teklad动物饲料Brexit FAQs

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Brexit FAQs

Brexit FAQs

Envigo is continuously monitoring, preparing and updating its guidance to customers as we approach the key dates of the Article 50 separation of the United Kingdom from the European Union (aka “Brexit”). Envigo established a Brexit task force consisting of senior leadership from key areas of our business to ensure ongoing business continuity for both Envigo and its customers.

This task force continues to meet regularly in order to prepare and implement business process plans and resourcing to anticipate and minimize the impact of Brexit on our business. The following FAQs have been prepared as current guidance and is continually updated as the position between the British Government and the EU develops.

Brexit is a priority for Envigo and if you have any concern, please contact us at brexit@envigo.com.

Download the Brexit FAQs .

    Trade (Import / Export / Supply Chain)

  • Will there be tariffs applied to animal costs under WTO?

    Laboratory animals currently have no tax added for movement in to the EU and across the EU, this position will remain the same under WTO

    Prices for 2021 are being reviewed as normal and will be confirmed in due course.

  • Will there be changes in documentation needed for movements of animals in or out of the UK?

    Import to UK Changes:
    Envigo’s current understanding is that there will be limited change in terms of documentation required. 

    DEFRA have now confirmed that no additional vet checks on arrival will be required

    Also customers can use the AHPA License for the import into the UK of live rodents or lagomorphs for research. Our Customer Services team are talking to the relevant customers and can advise any new customers as required

    Our Customer Services team is working directly with customers to make the necessary changes to Incoterms

    Export from UK Changes:
    Envigo understands that the export documentation will need to be agreed with the EU and may require an additional licence per shipment. This may take an additional time to secure plus an additional vet check may be required prior to shipment. We are working with EU groups to clarify this position and will update customers once a firm position is confirmed.

    Documentation:
    Exact documentation requirements are to be clarified, please contact your customer services representative if you have immediate concerns.

  • Will there be any other impact on the movement of animals in and out of the UK?

    The main impact we currently predict is additional delays in shipments due to:

    Export license requests may add time to the process from PO to shipment for small animals being shipped from the UK to the EU. Vet checks might be required at Border Inspection Posts at the airport of arrival.

    Additional CITES might be required and thus may add additional time for shipments of animals requiring to travel under CITES from the EU to the UK.

  • Will there be tariffs on any other goods imported in and out of the UK under WTO?

    Under WTO terms the Envigo team have assessed that there will be additional tariffs on certain goods including our Teklad diet shipments into the UK. Additional costs are being assessed and any cost impact to clients will be conveyed to customers via our commercial sales team as soon as possible.

  • Has Envigo ensured that its supply chain for its Operations are ready for the change on 1st Jan?

    Envigo’s Procurement team continues to work with it’s key suppliers in the UK to ensure that supply chains are secure for the post Brexit period. The team are encouraging suppliers to ensure that they have sufficient stock to cover any transition period at the beginning of January.

  • What will the impact be on the movement of biological products (UK to customer EU and EU to UK)?

    We are working with the governmental authorities in the relevant countries together with our international couriers to determine labelling / commercial invoice / payment of VAT / export license & vet check requirements. We will update all parties once further clarity is obtained. We are sure that this will be determined to ensure continuity of these services as we transition to the post Brexit position.

  • Does Envigo think movement of animals in and out of the UK will have the changes in place ready for 1st Jan?

    Envigo recommends that its clients do not request animals deliveries in or out of the UK during the first two weeks of January in order to ensure that all changes at borders and documentation are in place. If there is a requirement for a shipment early in January we would request that you contact your customer services representative as early as possible in December order that the necessary plans can be put in place.

  • Are there any specific concerns in relation to shipments to Ireland?

    The changes in movement of goods from UK to both Northern and Southern Ireland is still unknown – further clarification will be provided when we have more information.

    Talent

  • What proportion of Envigo’s UK employees are EU nationals?

    Less than 6% of Envigo’s UK employees are EU nationals. We have worked with all of these employees to ensure they have the relevant rights to live / work in the UK or EU as appropriate

  • What is Envigo’s expectation of the impact of immigration challenges to staffing your UK-based operation?

    This is not expected to have significant impact as Envigo has separate distribution centres in both the UK and EU to enable us to continue to operate under the most favourable trading environment for our customers regardless of trading arrangements between the UK and the EU, or between the UK, EU and the rest of the world. We are committed to recruiting and retaining the best people and to pursue our mission to be the best company to work with and the best company to work for.

    Financial

  • What will be the impact on Envigo’s finances?

    Envigo is financially stable and resilient: Though there might be minor changes arising from the Brexit transition, we believe that there will not be any significant adverse impact to the business and we will continue to invest in world-class operations and innovation post Brexit.

  • Impact of exchange rate movements on costs, profitability and competitive position

    Exchange rate movements are an inevitable fact of the business environment and occur because of numerous factors including, inflation, government fiscal policy, real gross domestic product GDP and expectations around future economic performance and the impact of speculative currency investment. In this regard, they are not deemed to be solely a Brexit specific issue. Exchange rate risk is mitigated by Envigo due it being an international business, which has regional operational centres in proximity to the customer base incurring costs in the same currency of sale.

    Data Protection/GDPR

  • What is will be the status of the General Data Protection Regulation (2016/679) (GDPR) after the transition period.

    The UK is committed to maintaining the high standards of the GDPR and the government plans to incorporate it via the European Union (Withdrawal) Act 2018 into UK law alongside the Data Protection Act 2018, at the end of the transition period.

  • What safeguards will be in place for 1. UK to EEA Personal Data flows; 2. EEA to UK Personal Data flows; and, 3. UK sharing data outside the EEA after the transition period?
    1. The UK government has stated that transfers of Personal Data to the EEA will not be restricted and that no additional steps are necessary at this time.
    2. The European Commission is presently deliberating on an adequacy decision under Article 45(3) of the GDPR which would enable the transfer of personal data from EEA states to the UK without requiring any further safeguards. Pending such an adequacy decision or in the absence thereof, Envigo is putting in place approved safeguards in the form of standard contractual clauses.
    3. Rules for sharing data with countries outside the EEA will remain similar.The UK government has confirmed that there will be transitional provisions to recognise existing EU adequacy decisions and EU-approved transfers safeguards.

    Other

  • What Brexit scenario is Envigo planning for?

    At this stage Envigo is planning for a “no-deal” scenario and have put the necessary actions in place to manage its business on this basis

  • Has Envigo undertaken an internal assessment of what impact Brexit will have on customer’s business operations?

    Yes, Envigo continues to assess the potential impact of Brexit on both our customers and suppliers. In response to Brexit we have:

    • Our internal task force is continuously assessing the overall business risks
    • Developing a range of contingency plans to mitigate the effects
    • Envigo are taking a leading role and working with various industry associations. ABPI, BIA, EARA, and UK government departments (e.g. DEFRA, Home office, Her Majesty’s Revenue and Customs (HMRC)). At this stage there are still uncertainties on specific issues e.g. CITES and as such there are still risks that we continue to try and mitigate against. As a result, we would recommend that cross border shipment in the first two weeks of January be avoided.
  • Have you developed a plan to mitigate the Brexit risks you have identified?

    Yes, and are already initiating action and contingency plans to address potential impacts on our business based upon our current understanding.

  • Does Envigo review and adjust plans based on Brexit negotiations and wider external events?

    Yes, our internal task force is continuously assessing the overall business risks, to ensure the plans are both relevant and appropriate to the current political situation.

  • Whom may we contact to follow up on the responses to Brexit mitigation plans?

    An e-mail address has been established: brexit@envigo.com. This is available for use to allow any specific follow up questions to be raised that you might have in relation to Envigo’s Brexit mitigation plans.

Glossary

ABPI Association of British Pharmaceutical Industry
BIA  Bioindustry Association
CLP  Classification, Labelling and Packaging
CITES  Convention on International Trade in Endangered Species of Wild Fauna and Flora (also known as the Washington Convention)
DEFRA  Department for Environment, Food and Rural Affairs
DPB  Data Protection Bill
EARA  European Animal Research Association
EU27  European Union (the 27 European Union countries involved in Brexit negotiations)
EUWB  European Withdrawal Bill
GDPR  General Data Protection Regulation
HMRC  Her Majesty’s Revenue and Customs
PII  Personally Identifiable Information
WTO  World Trade Organization

Harlan Teklad动物饲料Accessibility statement

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Accessibility statement

Accessibility statement

Updated: February 2021

As recently as December 2020, the World Health Organization estimated that there are more than one billion people living with disabilities, with over 100 million persons having significant difficulties in functioning (for more information, see www.who.int/disabilities/en).

Many of these disabilities can affect access to information technologies. Additionally, the same individuals who run into barriers that impede access to information technologies could benefit most from using them.

Given the importance of the internet, accessibility to the web is of critical importance to people with disabilities around the world, including people with auditory, cognitive, physical, neurological, and visual disabilities. It is likewise important to those with accessibility needs due to aging.

Providing accessible web content can also benefit people who do not have disabilities but who are experiencing situational barriers. For example, when accessing the internet from devices with small screens or in low bandwidth situations, or when experiencing barriers due to language or literacy levels, accessibility solutions can also support improved access.

Envigo is committed to ensuring equal access for people with disabilities. As potential stakeholders, customers and employees of Envigo, they are important contributors to Envigo’s business success and should not be excluded, but rather welcomed into the Envigo family.

Envigo will endeavor to maximize the access of people with disabilities to this website.

Web content produced by Envigo is intended to meet Web Content Accessibility Guidelines (WCAG) 2.1, Level AA by the target compliance date of February 2021.

Envigo enables web content accessibility utilizing a third-party tool. It is our intent to provide full WCAG compliant content however we cannot guarantee browser specific behavior and/or remote sites.

If you have any questions, please contact us marketing@envigo.com.

Harlan Teklad动物饲料Terms of use

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Terms of use

Terms of use

Website Use / Legal Notices and Disclaimers

 

1. ACCEPTANCE OF TERMS

The following agreement outlines your obligations when using the Envigo website available at <Envigo.com>, (the “Site”).  The Site is owned and operated by Envigo RMS, LLC (“Envigo”), and is accessed by you under the terms of use described below (“Terms of Use”).  PLEASE READ THESE TERMS OF USE CAREFULLY BEFORE USING THE SERVICES.  BY ACCESSING THE SITE OR ANY CONTENT ON THE SITE, YOU AGREE TO BECOME BOUND BY THESE TERMS AND CONDITIONS.  IF YOU DO NOT AGREE TO ALL THE TERMS AND CONDITIONS, THEN YOU MAY NOT ACCESS THE SITE OR USE THE CONTENT OR ANY SERVICES IN THE SITE.  ENVIGO’S ACCEPTANCE IS EXPRESSLY CONDITIONED UPON YOUR ASSENT TO ALL OF THESE TERMS AND CONDITIONS, TO THE EXCLUSION OF ALL OTHER TERMS; IF THESE TERMS AND CONDITIONS ARE CONSIDERED AN OFFER BY ENVIGO, ACCEPTANCE IS EXPRESSLY LIMITED TO THESE TERMS.

2. MODIFICATIONS OF TERMS OF USE

Envigo reserves the right, at its sole discretion, to modify or replace the Terms of Use at any time.  If the alterations constitute a material change to the Terms of Use, Envigo will notify you by posting an announcement on the Site.  What constitutes a “material change” will be determined at Envigo’s sole discretion, in good faith and using common sense and reasonable judgment.  You are responsible for reviewing and becoming familiar with any such modifications.  Use of the Site by you following such notification constitutes your acceptance of the terms and conditions of the Terms of Use as modified.

3. Content ownership and Usage Rights

Envigo shall retain all worldwide rights in the intellectual property of the Site, including, but not limited to, trademarks, the “look and feel” of the Site, its color combinations, layout, and all other graphical elements, and the copyright in and to its original content.  You should assume that everything you read or see on the Site is copyrighted or otherwise protected and owned by Envigo, or a third party who licensed the right to use such content to Envigo.  Unless otherwise expressly noted, nothing that you read or see on the Site or other site content, or any of the source code or HTML code that Envigo uses to generate the Site may be copied, reproduced, modified, distributed, transmitted, republished, displayed, or performed for commercial use without the prior written consent of Envigo, except as provided in the Terms of Use without prior written consent or otherwise permitted by relevant law.

4. PRIVACY POLICY

Envigo’s current privacy policy is available at www.envigo.com/privacy-policy (the “Privacy Policy”), which is incorporated by this reference.

5. INDEMNITY

You will indemnify and hold harmless Envigo, its parents, subsidiaries, affiliates, customers, vendors, officers and employees from any liability, damage or cost (including reasonable attorneys. fees and cost) from any claim or demand made by any third party due to or arising out of your access to the Site, use of the Services, violation of the Terms of Use by you, or the infringement by you of any intellectual property or other right of any person or entity.

6. WARRANTY DISCLAIMERS

Diligent care has been taken in acquiring and providing the information included and posted on the Site.  Nonetheless, Envigo makes no guarantee or warranty, express or implied, as to the reliability, accuracy, timeliness or completeness of that information and assumes no responsibility for any errors or omissions therein.  USER ACCESSES THIS SITE AT HIS OR HER OWN RISK. THE SITE IS PROVIDED ON AN “AS IS, AS AVAILABLE” BASIS WITHOUT WARRANTY OF ANY KIND AND ANY AND ALL WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR NON-INFRINGEMENT ARE SPECIFICALLY DISCLAIMED. NEITHER ENVIGO NOR ITS AFFILIATES, EMPLOYEES, AGENTS OR THIRD PARTY CONTENT PROVIDERS SHALL BE LIABLE FOR ANY LOSS RESULTING FROM USE OR UNAVAILABILITY OF INFORMATION OR CONTENT ON THIS SITE, INCLUDING BUT NOT LIMITED TO ANY LOST PROFITS, LOSS OR DAMAGE TO DATA, OR ANY DIRECT, INDIRECT, SPECIAL, CONSEQUENTIAL, COMPENSATORY OR INCIDENTAL DAMAGES, EVEN IF THEY HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.  THIS DISCLAIMER IS APPLICABLE TO ANY DAMAGE OR INJURY RESULTING FROM NEGLIGENCE OR OMISSION OF ENVIGO, COMPUTER VIRUS OR OTHER SIMILAR ITEM, TELECOMMUNICATIONS ERRORS, OR UNAUTHORIZED ACCESS TO OR USE OF USER INFORMATION THROUGH THEFT OR ANY OTHER MEANS.  ENVIGO IS NOT LIABLE FOR CRIMINAL, TORTUOUS, OR NEGLIGENT ACTIONS OR OMISSIONS OF THIRD PARTIES THAT AFFECT THIS SITE.  IN NO EVENT WILL ENVIGO OR ANY OF ITS AFFILIATES, AGENTS, EMPLOYEES, ASSIGNS OR THIRD PARTY CONTENT PROVIDERS BE HELD LIABLE FOR ANY TORTUOUS OR ILLEGAL CONDUCT OF OTHER USERS.  IN NO EVENT WILL ENVIGO OR ANY OF ITS AFFILIATES, AGENTS, EMPLOYEES OR ASSIGNS BE HELD LIABLE FOR ANY DAMAGE TO EQUIPMENT, HARDWARE OR OTHER PROPERTY OF USER OR PERSONAL INJURY THAT ARISES IN CONNECTION WITH USE OF THE SITE.

7. Linking and Framing

Envigo does not object to links on third-party sites to the homepage of the Site in an appropriate context.  However, “framing” or “mirroring” the Site or any of its content is prohibited without the prior written consent of Envigo.

The Site may provide links to other sites or resources available on the Internet.  Because Envigo has no control over such sites and resources, you acknowledge and agree that Envigo is not responsible for the availability of such external sites or resources, and does not endorse and is not responsible or liable for any content, advertising, products or other materials on or available from such sites or resources.  You further acknowledge and agree that Envigo shall not be responsible or liable, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with use of or reliance on any such content, goods or services available on or through any such site or resource.

8. Trademarks and trade names

ENVIGO, TEKLAD GLOBAL DIETS, SD, HOLTZMAN, SPRAGUE DAWLEY, Envigo graphics, logos, designs, page headers, button icons, scripts, and other service names are the trademarks and trade names of Envigo. Envigo’s trademarks and trade names may not be used, including as part of trademarks and/or as part of domain names, in connection with any product or service in any manner that is likely to cause confusion.

9. Electronic Communications

We use reasonable security measures and take reasonable system, process and administrative precautions to protect the security and integrity of email and other electronic communications that you may send to us.  Despite all these precautions, no method of transmission over the Internet is entirely secure and we cannot guarantee the confidentiality or security of the electronic communications or its contents.  You transmit such information at your own risk and you should decide very carefully which information you want to send us via any electronic communication.

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Users are prohibited from violating or attempting to violate the security of the site.  Envigo will investigate occurrences of possible violations and will cooperate with all applicable law enforcement authorities in prosecuting violators.

11. Miscellaneous

The Terms of Use constitutes the entire agreement between users of the Site and Envigo, and regarding the subject matter hereof.  If you breach any term of the Terms of Use, Envigo may pursue any legal or equitable remedy available, including but not limited to, direct, consequential, and punitive damages and injunctive relief.  Envigo remedies are cumulative and not exclusive.  Failure of Envigo, to exercise any remedy or enforce any portion of the Terms of Use at any time shall not operate as a waiver of any remedy or of the right to enforce any portion of the Agreement at any time thereafter.  Users of this Site are responsible for compliance with all applicable regulations and laws.  Any dispute arising out of the Terms of Use shall be governed by the laws of Indiana, notwithstanding any conflicts of law principles. Any action relating to the Terms of Use must be filed and maintained in a court in the state of Indiana, USA, and users consent to exclusive jurisdiction and venue in such courts for such purpose.

Harlan Teklad动物饲料LabTracks

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LabTracks web portal

LabTracks

Working with Envigo, you are only a mouse click away from accessing the data for your projects. Customers have access to the same systems that Envigo uses to provide the services you require. As the system is updated by Envigo, customers have real time access to the same information. Generate a report or analyze your study data through a secure technology platform.

LabTracks

Login is associated with the location of your colonies.

Envigo LabTracks provides access to the same system used to manage your colony within our facilities. Access the system to view your projects, request a task or generate an update report.

Harlan Teklad动物饲料Vision, mission and values

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Vision, mission and values

Vision, mission and values

Vision

Working together to build a healthier and safer world

Mission

To be the best company to work with and the best company to work for

Values

Doing our best work, together, every day
Caring about each other, our animals and the environment
Being honest and respectful
Always learning, challenging and improving

Harlan Teklad动物饲料Customer supplied ingredients

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Customer supplied ingredients

Customizing diets for all types of research needs

Customer supplied ingredients

When your experiments require the addition or application of certain compounds to your animal research subject, you can consider adding your medications or compounds to your animal’s diet. Envigo has experience customizing diets for all types of research needs, and that includes introducing additives as a convenient way to medicate lab animals. Simply turn to one of our expert staff nutritionists to determine whether it is a viable option.

Medications or compounds supplied by your investigator are referred to as “customer supplied ingredients” or “customer reserves,” and they can be added to most diets. Generally, if the stability or activity of the compound is not compromised during manufacture or further processing such as irradiation, adding an ingredient can be a smart option for simplifying your feeding and medicating schedules. Also, the inclusion rate of any given compound is adjusted to suit your needs, and can be determined in consultation with our expert nutritional staff.

Please use the customer supplied ingredients submission form if you require the addition or application of certain compounds to your animal research subject.

Some common customer supplied compounds include:

  • Cuprizone (also now stocked)
  • Tamoxifen (also now stocked: US, EU)
  • Purified fatty acids (DHA, EPA)
  • Curcumin
  • Rosiglitazone
  • Statins
  • Antibiotics
  • Valproate
  • Piroxicam
  • Berry powders
  • Bisphenol A (BPA, in diluted form)

When adding a compound to a diet, we will work with you to be sure that it is appropriate for our diet formulation procedures and can be done safely.

  • We require a safety data sheet or other relevant safety and usage information
  • We have an obligation to maintain a safe work environment. This typically applies to drugs, experimental compounds and chemicals
  • Food products generally will not require safety information, although information about nutrient content, reason for use, etc. is helpful in the design of diets

  • Water is added as a pelleting aid. Pellets are formed under pressure but no external heat is applied
  • Sometimes the drying process can be modified if heat stability is questioned
  • It is your responsibility to determine the suitability of the compound for inclusion into a pelleted diet

  • If you require irradiation, we can customize most diets to be suitable for this sterilization process
  • Once your diet has been produced, we can send it for irradiation. The dose ranges from 20-50 kGy. Diets that are to be irradiated require an additional two weeks for shipment (four weeks total)
  • For diets that are to be irradiated, vacuum packaging may be beneficial. Both irradiation and vacuum packaging must be requested when ordering
  • We defer to you to determine the suitability of the compound for irradiation

  • Inform us on a g/kg diet or percentage basis, how much of the compound you want in the diet
  • If you need to calculate a dose based on animal body weight, we can help convert that to g/kg diet
  • Depending on the choice of base diet and the nature of the added ingredient(s), more than a ten percent dilution is generally not advisable
  • To limit differences between the control and experimental diets you may want to consider using a control diet that uses similar ingredients and has gone through the same production process

  • Send extra compound (approximately enough for one more kg than you have ordered) so that we can yield the desired amount of diet
  • If we have not received enough compound, we will use the entire amount and make as much diet as possible, unless special arrangements can be made

  • If you plan to use the compound more than once and stability with storage is not an issue, we can maintain an inventory for you and store it appropriately, per your instructions
  • Unless otherwise instructed, we will return any remaining compound with your shipment, but we do not dispose of the compound
  • If you would like your compound retained for future use, please supply us with a retention document

Harlan Teklad动物饲料Envigo global locations

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Global locations

Envigo has over 1,200 devoted employees in more than 20 locations across North America and Europe who provide our customers with mission-critical products and services to enable their critical research.
North America | Europe | Middle East

Envigo global locations

Harlan Teklad动物饲料Isoflavone adjusted

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Isoflavone adjusted

Isoflavone adjusted

Isoflavones, a type of phytoestrogen, are found in soy protein. Most traditional standard diets have soybean meal as a major ingredient, and therefore are a significant source of isoflavones. Please refer to FAQ section for more information about phytoestrogens.

In contrast, casein-based purified diets such as AIN-76A, AIN-93G, AIN-93M, and formulas with similar ingredients, are essentially free of isoflavones. This type of diet is sometimes used for research that requires a minimal isoflavone background. This type of diet can be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

An alternative to a purified, casein-based diet is a natural ingredient diet from our global rodent diet line. Several diets in this line contain minimal isoflavone/phytoestrogen levels and are commonly used for research that requires a minimal isoflavone/phytoestrogen background. This type of diet can also be used as the background to which isoflavones such as genistein (supplied by the customer) can be added.

Harlan Teklad动物饲料Our brand story

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Our brand story

Our brand story

Envigo’s customers conduct research and develop products that have the potential to improve lives. But achieving this potential is becoming increasingly difficult.

We believe that for our customers to achieve their goals, they need to trust and be absolutely confident in the company they choose to help them with their research, products and services.

We understand the only way we can create this trust and confidence is by consistently delivering scientific excellence and outstanding customer service.

At Envigo, we are proud of our customer-centric culture which makes us responsive to every customer, no matter their size, continually optimizing their product delivery and research programs to help ensure consistently clear results.

Our ability to combine scientific excellence with empathetic working relationships is what differentiates us. We always seek to understand our customers’ goals and challenges, appreciate our customers’ perspectives and work together for a better future.

Beyond our responsibility to customers, we are responsible to people, animals and the communities and environment in which we live. We are dedicated to assuring people that the products they use have been tested properly for safety and efficacy. We are committed to the highest levels of animal welfare. And we provide services that help develop new medicines, protect the environment and food supplies and make the world a healthier and safer place.

At Envigo, we exist to help our customers secure the potential of their research and develop products that enhance and enrich life.

Our brand story

 

 

Harlan Teklad动物饲料Cookie statement

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Cookie statement

Cookie statement

Manage cookies

You may change your cookie preferences here:

 

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Harlan Teklad动物饲料2019 Teklad global 19% protein extruded rodent diets

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2019 Teklad global 19% protein extruded rodent diets

2019 Teklad global 19% protein extruded rodent diets

Product Features

  • Designed to support gestation, lactation, and growth of rodents
  • Useful for poorly breeding strains of rodents and genetically engineered stocks and strains
  • Extruded form ensures that despite its high fat content, it remains firm with minimal wastage
  • Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
  • Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
  • Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity
  • Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

Products

Teklad rodent diets Non-autoclavable form Autoclavable Irradiated
Teklad global 19% protein extruded 2019 2019S 2919

Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.

Harlan Teklad动物饲料AIN diet formulas

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AIN diet formulas

AIN diet formulas

These formulas are purified diets with commonly used refined ingredients. These basic formulas are often modified for a specific research purpose, such as altering the fat source, a vitamin or mineral level, or adding a compound. See the FAQ section to learn more about the history of these formulas, AIN-76A, AIN-93G, and AIN-93M.

These formulas (as well as other purified diets) do not contain alfalfa and can be used to reduce background autofluorescence in certain imaging applications. Our Global Rodent Diets are also alfalfa-free and are suitable for imaging work. Please contact us for further information about these formulas or modifications.

Other related product codes:

  • TD.94096   version of AIN-76A suitable for irradiation (vitamin levels are increased)
  • TD.97184   version of AIN-93G suitable for irradiation (vitamin levels are increased)
  • TD.00102   version of AIN-93M suitable for irradiation (vitamin levels are increased)
  • TD.95092   modification of AIN-93G where soybean oil is replaced with corn oil

Harlan Teklad动物饲料2014 Teklad global 14% protein rodent maintenance diets

上海金畔生物科技有限公司代理Harlan Teklad动物饲料全线产品,欢迎访问Harlan Teklad动物饲料官网了解更多信息。

2014 Teklad global 14% protein rodent maintenance diets

2014 Teklad global 14% protein rodent maintenance diets

Product Features

  • Designed to promote longevity and normal body weight
  • Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
  • Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
  • Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imaging clarity
  • Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

Products

Teklad rodent diets Non-autoclavable form Autoclavable Irradiated
Teklad global 14% protein 2014 , 2014C 2014S 2914

Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.

Harlan Teklad动物饲料Accreditations and certifications

上海金畔生物科技有限公司代理Harlan Teklad动物饲料全线产品,欢迎访问Harlan Teklad动物饲料官网了解更多信息。

Accreditations and certifications

Accreditations and certifications

At Envigo, we are dedicated to providing a broad range of research models and related services to the pharmaceutical and biotechnology industries, government, academia, and other life science organizations. We are committed to helping researchers realize the full potential of their critical research projects as we fulfill our mission to work together to build a healthier and safer world.

In order to build trust and confidence with our customers, we strive to consistently deliver scientific excellence. Included below is a list of our most recent certificates and accreditations.

Accreditations and certifications

Certifications

 

Accreditations and certifications

Accreditations

 

Harlan Teklad动物饲料Privacy policy

上海金畔生物科技有限公司代理Harlan Teklad动物饲料全线产品,欢迎访问Harlan Teklad动物饲料官网了解更多信息。

Privacy policy

Privacy policy

Last Updated 10 November 2020

Envigo respects your privacy and is committed to protecting your personal data. This privacy notice will inform you what personal information we may collect about you when you interact with Envigo and its group of companies (“Envigo,” “we,” “us,” and “our,”), how we look after your personal data and tell you about your privacy rights and how the law protects you.

It is important that you read this Privacy Policy together with any other privacy notice or fair processing notice we may provide on specific occasions when we are collecting or processing personal data about you so that you are fully aware of how and why we are using your data.

This privacy notice supplements the other notices and is not intended to override them. We may change this Privacy Policy from time to time.

This website is not intended for children and we do not knowingly collect data relating to children.

Third-party links

This website may include links to third-party websites, plug-ins and applications. Clicking on those links or enabling those connections may allow third parties to collect or share data about you. We do not control these third-party websites and are not responsible for their privacy statements. When you leave our website, we encourage you to read the privacy notice of every website you visit.

1. The data we collect about you

Personal data, or personal information, means any information about an individual from which that person can be identified. It does not include data where the identity has been removed (anonymous data).

We may collect, use, store and transfer different kinds of personal data about you which we have grouped together follows:

  • Identity Data includes first name, last name, username or similar identifier, title, date of birth and gender.
  • Contact Data includes, email address and telephone numbers, job title, IP Address, employer.
  • Technical Data includes internet protocol (IP) address, your login data, browser type and version, time zone setting and location, browser plug-in types and versions, operating system and platform and other technology on the devices you use to access this website.
  • Profile Data includes your username, areas of research, areas of interest, preferences, feedback and survey responses, role in purchasing
  • Usage Data includes information about how you use our website.
  • Marketing and Communications Data includes your preferences in receiving marketing from us and our third parties and your communication preferences.

We also collect, use and share Aggregated Data such as statistical or demographic data for any purpose. Aggregated Data may be derived from your personal data but is not considered personal data in law as this data does not directly or indirectly reveal your identity. For example, we may aggregate your Usage Data to calculate the percentage of users accessing a specific website feature. However, if we combine or connect Aggregated Data with your personal data so that it can directly or indirectly identify you, we treat the combined data as personal data which will be used in accordance with this Privacy Policy.

If you fail to provide personal data

Where we need to collect personal data by law, or under the terms of a contract we have with you and you fail to provide that data when requested, we may not be able to perform the contract we have or are trying to enter into with you (for example, to provide you with goods or services). In this case, we may have to cancel a product or service you have with us but we will notify you if this is the case at the time.

2. How is your personal data collected?

We use different methods to collect data from and about you including through:

  • Direct interactions. You may give us your Identity and Contact by filling in forms or by corresponding with us by post, phone, email, website, digital platforms or otherwise. This includes personal data you provide when you:
    • apply for our products or services;
    • subscribe to our service or publications;
    • request access to or be sent marketing content
    • enter a competition, promotion, survey or register for an event; or
    • give us some feedback.
  • Automated technologies or interactions. As you interact with our website, we may automatically collect Technical Data about your equipment, browsing actions and patterns. We collect this personal data by using cookies, server logs and other similar technologies. We may also receive Technical Data about you if you visit other websites employing our cookies. Please see our cookie statement for further details.
  • Third parties or publicly available sources. We may receive personal data about you from various third parties and public sources as set out below:
    • Technical Data from the following parties:
      (a) analytics providers such as Google based outside the EU,
      (b) advertising networks,
      (c) search information providers.
  • Identity and Contact Data from publicly availably sources such as relevant Company Registers.

3. How we use your personal data

We will only use your personal data when the law allows us to. Most commonly, we will use your personal data in the following circumstances:

  • Where we need to perform the contract we are about to enter into or have entered into with you.
  • Where it is necessary for our legitimate interests (or those of a third party) and your interests and fundamental rights do not override those interests.
  • Where we need to comply with a legal or regulatory obligation.
  • Where it is necessary to protect the vital interests of the individual or another person.
  • Generally we do not rely on consent as a legal basis for processing your personal data other than in relation to sending direct marketing communications. You have the right to withdraw consent to marketing at any time by visiting our contact preference center or by contacting us directly. A link to our contact preference center is available in all email communications.

Purposes for which we will use your personal data

We have set out below, in a table format, a description of all the ways we plan to use your personal data, and which of the legal bases we rely on to do so. We have also identified what our legitimate interests are where appropriate.

Note that we may process your personal data for more than one lawful ground depending on the specific purpose for which we are using your data. Please contact us if you need details about the specific legal ground we are relying on to process your personal data where more than one ground has been set out in the table below.

Purpose/Activity Type of data Lawful basis for processing including basis of legitimate interest
To register you as a new customer (a) Identity
(b) Contact
Performance of a contract
To manage our relationship with you which will include:
(a) Notifying you about changes to our terms or Privacy Policy
(b) Asking you to leave a review or take a survey.
(a) Identity
(b) Contact
(c) Profile
(d) Marketing and Communications
(a) Performance of a contract with you
(b) Necessary to comply with a legal obligation
(c) Necessary for our legitimate interests (to keep our records updated and to study how customers use our products/services)
To enable you to complete a survey, sign up for an event, subscribe for information or updates. (a) Identity
(b) Contact
(c) Profile
(d) Usage
(e) Marketing and Communications
(a) Performance of a contract with you
(b) Necessary for our legitimate interests (to study how customers use our products/services, to develop them and grow our business)
To administer and protect our business and this website (including troubleshooting, data analysis, testing, system maintenance, support, reporting and hosting of data) (a) Identity
(b) Contact
(c) Technical
(a) Necessary for our legitimate interests (for running our business, provision of administration and IT services, network security, to prevent fraud and in the context of a business reorganisation or group restructuring exercise)
(b) Necessary to comply with a legal obligation
To deliver relevant website content, general marketing and messaging to you and measure or understand the effectiveness of the advertising we serve to you (a) Identity
(b) Contact
(c) Profile
(d) Usage
(e) Marketing and Communications
(f) Technical
Necessary for our legitimate interests (to study how customers use our products/services, to develop them, to grow our business and to inform and measure our marketing strategy)
To use data analytics to improve our website, products/services, marketing, customer relationships and experiences (a) Technical
(b) Usage
Necessary for our legitimate interests (to define types of customers for our products and services, to keep our website updated and relevant, to develop our business and to inform our marketing strategy)
To make suggestions and recommendations to you about goods or services that may be of interest to you (a) Identity
(b) Contact
(c) Technical
(d) Usage
(e) Profile
Necessary for our legitimate interests (to develop our products/services and grow our business)

Marketing

We strive to provide you with choices regarding certain personal data uses, particularly around marketing and advertising, via the contact preference center, available in all email communications, or by contacting us at any time.

Promotional offers from us

We may use your Identity, Contact, Technical, Usage and Profile Data to form a view on what we think you may want or need, or what may be of interest to you. This is how we decide which products, services and offers may be relevant for you.

You will receive marketing communications from us if you have requested information from us or purchased goods or services from us or if you provided us with your details when you entered a competition, registered for a promotion or for an event and, in each case, you have not opted out of receiving that marketing.

Third-party marketing

We will get your express opt-in consent before we share your personal data with any company outside the Envigo group of companies for marketing purposes.

Opting out

You can ask us to stop sending you marketing messages at any time via the contact preference center, available in all email communications, or by contacting us at any time.

Where you opt out of receiving these marketing messages, this will not apply to personal data provided to us as a result of a product/service purchase, product/service experience or other transactions.

Cookies

You can set your browser to refuse all, or to alert you when websites set or access cookies. If you disable or refuse cookies, please note that some parts of this website may become inaccessible or not function properly. For more information about the cookies we use, please see our cookie statement.

Change of purpose

We will only use your personal data for the purposes for which we collected it, unless we reasonably consider that we need to use it for another reason and that reason is compatible with the original purpose. If we need to use your personal data for an unrelated purpose, we will notify you and we will explain the legal basis which allows us to do so.

Please note that we may process your personal data without your knowledge or consent, in compliance with the above rules, where this is required or permitted by law.

4. Disclosures of your personal data

We may have to share your personal data with the parties set out below for the purposes set out in the table in paragraph 3 above.

  • Internal Third Parties as set out in the Glossary below.
  • External Third Parties as set out in the Glossary below.
  • Third parties to whom we may choose to sell, transfer, or merge parts of our business or our assets. Alternatively, we may seek to acquire other businesses or merge with them. If a change happens to our business, then the new owners may use your personal data in the same way as set out in this privacy notice.

We require all third parties to respect the security of your personal data and to treat it in accordance with the law. We do not allow our third-party service providers to use your personal data for their own purposes and only permit them to process your personal data for specified purposes and in accordance with our instructions.

5. International transfers

We share your personal data within the Envigo Group. This will involve transferring your data outside the European Economic Area (EEA).

Some of our external third parties are based outside the European Economic Area (EEA) so their processing of your personal data will involve a transfer of data outside the EEA.

Whenever we transfer your personal data out of the EEA, we ensure a similar degree of protection is afforded to it by ensuring at least one of the following safeguards is implemented.

  • We will only transfer your personal data to countries that have been deemed to provide an adequate level of protection for personal data by the European Commission.
  • Where we use certain service providers, we may use specific contracts approved by the European Commission which give personal data the same protection it has in Europe.
  • Where we use providers based in the US, we may transfer data to them if they are part of the Privacy Shield (to the extent that it continues to provide adequate safeguards) which requires them to provide similar protection to personal data shared between the Europe and the US. For further details, see European Commission: EU-US Privacy Shield.

6. Data security

We have put in place appropriate security measures to prevent your personal data from being accidentally lost, used or accessed in an unauthorized way, altered or disclosed. In addition, we limit access to your personal data to those employees, agents, contractors and other third parties who have a business need to know. They will only process your personal data on our instructions and they are subject to a duty of confidentiality.

We have put in place procedures to deal with any suspected personal data breach and will notify you and any applicable regulator of a breach where we are legally required to do so.

7. Data retention

How long will you use my personal data for?

We will only retain your personal data for as long as necessary to fulfil the purposes we collected it for, including for the purposes of satisfying any legal, accounting, or reporting requirements.

To determine the appropriate retention period for personal data, we consider the amount, nature, and sensitivity of the personal data, the potential risk of harm from unauthorised use or disclosure of your personal data, the purposes for which we process your personal data and whether we can achieve those purposes through other means, and the applicable legal requirements.

In some circumstances you can ask us to delete your data: see Request erasure below for further information.

In some circumstances we may anonymise your personal data (so that it can no longer be associated with you) for research or statistical purposes in which case we may use this information indefinitely without further notice to you.

8. Your legal rights

Under certain circumstances, you have rights under data protection laws in relation to your personal data. You may be entitled to:

  • Request access to your personal data.
  • Request correction of your personal data.
  • Request erasure of your personal data.
  • Object to processing of your personal data.
  • Request restriction of processing your personal data.
  • Request transfer of your personal data.
  • Right to withdraw consent.

You also have the right to complain to your local data protection authority if your privacy rights are violated, or if you have suffered as a result of unlawful processing of your personal information. We would however welcome the opportunity to resolve any issue that you have.

If you wish to exercise any of the rights set out above, please contact us.

No fee usually required

You will not have to pay a fee to access your personal data (or to exercise any of the other rights). However, we may charge a reasonable fee if your request is clearly unfounded, repetitive or excessive. Alternatively, we may refuse to comply with your request in these circumstances.

What we may need from you

We may need to request specific information from you to help us confirm your identity and ensure your right to access your personal data (or to exercise any of your other rights). This is a security measure to ensure that personal data is not disclosed to any person who has no right to receive it. We may also contact you to ask you for further information in relation to your request to speed up our response.

Time limit to respond

We try to respond to all legitimate requests within one month. Occasionally it may take us longer than a month if your request is particularly complex or you have made a number of requests. In this case, we will notify you and keep you updated.

9. Glossary

LAWFUL BASIS

Legitimate Interest means the interest of our business in conducting and managing our business to enable us to give you the best service/product and the best and most secure experience. We make sure we consider and balance any potential impact on you (both positive and negative) and your rights before we process your personal data for our legitimate interests. We do not use your personal data for activities where our interests are overridden by the impact on you (unless we have your consent or are otherwise required or permitted to by law). You can obtain further information about how we assess our legitimate interests against any potential impact on you in respect of specific activities by contacting us.

Performance of Contract means processing your data where it is necessary for the performance of a contract to which you are a party or to take steps at your request before entering into such a contract.

Comply with a legal or regulatory obligation means processing your personal data where it is necessary for compliance with a legal or regulatory obligation that we are subject to.

THIRD PARTIES

Internal Third Parties

Other companies in the Envigo Group acting as joint controllers or processors and who are based in the USA, Europe and ROW and provide products and services and IT and system administration services and undertake leadership reporting.

External Third Parties

  • Service providers acting as processors who provide IT and system administration services.
  • Professional advisers acting as processors or joint controllers including lawyers, bankers, auditors and insurers who provide consultancy, banking, legal, insurance and accounting services.
  • HM Revenue & Customs, regulators and other authorities acting as processors or joint controllers who require reporting of processing activities in certain circumstances.

YOUR LEGAL RIGHTS

You have the right to:

Request access to your personal data (commonly known as a “data subject access request”). This enables you to receive a copy of the personal data we hold about you and to check that we are lawfully processing it.

Request correction of the personal data that we hold about you. This enables you to have any incomplete or inaccurate data we hold about you corrected, though we may need to verify the accuracy of the new data you provide to us.

Request erasure of your personal data. This enables you to ask us to delete or remove personal data where there is no good reason for us continuing to process it. You also have the right to ask us to delete or remove your personal data where you have successfully exercised your right to object to processing (see below), where we may have processed your information unlawfully or where we are required to erase your personal data to comply with local law. Note, however, that we may not always be able to comply with your request of erasure for specific legal reasons which will be notified to you, if applicable, at the time of your request.

Object to processing of your personal data where we are relying on a legitimate interest (or those of a third party) and there is something about your particular situation which makes you want to object to processing on this ground as you feel it impacts on your fundamental rights and freedoms. You also have the right to object where we are processing your personal data for direct marketing purposes. In some cases, we may demonstrate that we have compelling legitimate grounds to process your information which override your rights and freedoms.

Request restriction of processing of your personal data. This enables you to ask us to suspend the processing of your personal data in the following scenarios: (a) if you want us to establish the data’s accuracy; (b) where our use of the data is unlawful but you do not want us to erase it; (c) where you need us to hold the data even if we no longer require it as you need it to establish, exercise or defend legal claims; or (d) you have objected to our use of your data but we need to verify whether we have overriding legitimate grounds to use it.

Request the transfer of your personal data to you or to a third party. We will provide to you, or a third party you have chosen, your personal data in a structured, commonly used, machine-readable format. Note that this right only applies to automated information which you initially provided consent for us to use or where we used the information to perform a contract with you.

Withdraw consent at any time where we are relying on consent to process your personal data. However, this will not affect the lawfulness of any processing carried out before you withdraw your consent. If you withdraw your consent, we may not be able to provide certain products or services to you. We will advise you if this is the case at the time you withdraw your consent.

Harlan Teklad动物饲料NAFLD and NASH

上海金畔生物科技有限公司代理Harlan Teklad动物饲料全线产品,欢迎访问Harlan Teklad动物饲料官网了解更多信息。

NAFLD and NASH

NAFLD and NASH

Dietary methods to induce NAFLD/NASH in rodents can be split into two common categories:

  • diets fed for longer periods of time to induce obesity, metabolic syndrome, and mild NASH or
  • diets fed for short periods of time to induce hepatic features of severe NASH without inducing obesity or insulin resistance

This page provides further information on dietary methods to induce NAFLD/NASH. We’ve also prepared a downloadable NASH/NAFLD mini paper.

The tables below highlight diet options from both of the above categories. For more complete descriptions of NAFLD/NASH models see the drop down menus that follow the tables.

Diet options for inducing obesity, metabolic syndrome and mild NAFLD/NASH

Diet features Western/Fast Food ALIOS FPC diet
Product Code TD.88137 TD.06303 TD.160785 PWD dough
Fat, % Kcal 42 45 52
Fat Sources, % by weight 21% milk fat 22% hydrogenated vegetable oil
1% soybean oil
19% hydrogenated vegetable oil
6% milk fat
4% palmitic acid
Fatty acid profile, % total fat 66% saturated
30% monounsaturated
4% polyunsaturated
23% saturated
31% monounsaturated (cis)
12% polyunsaturated (cis)
34% trans
43% saturated
27% monounsaturated (cis)
7% polyunsaturated (cis)
23% trans
Sugars, % by weight 34.5% sucrose 22.4% sucrose 34.5% sucrose
Cholesterol, % by weight 0.2 0 1.25
Modifications TD.96121 1.25% cholesterol
TD.120528 Increased sucrose, 1.25% cholesterol
TD.120330 0.2% cholesterol
TD.130885 0.2% cholesterol, 27% sucrose
TD.140154 adds customer supplied palmitic acid

For high fat diet options to induce uncomplicated NAFLD see our Diet Induced Obesity page.

Diet options for inducing more severe hepatic NAFLD/NASH without obesity or metabolic syndrome

Diet features High Fat, Cholesterol & Cholate Methionine/choline deficient (MCD)
Product Code TD.02028 TD.90262
Fat, % Kcal 42 22
Fat Sources, % by weight 21% milk fat 10% corn oil
Fatty acid profile, % total fat 66% saturated
30% monounsaturated
4% polyunsaturated
14% saturated
28% monounsaturated
58% polyunsaturated
Sugars, % by weight 33.3% sucrose 46% sucrose
Cholesterol, % by weight 1.25 0
Cholate Source, % by weight 0.5 0
Related diets TD.09237 15% milk fat, 1% cholesterol
TD.88051 Hybrid version
TD.94149 MCD control diet

    Diets inducing obesity, metabolic syndrome and mild NAFLD/NASH

  • Western and Fast Food diets with milkfat and cholesterol

    Western or fast food style diets fed to induce NASH with metabolic syndrome contain 40 – 45% kcal from milkfat (a fat source high in palmitate) with added cholesterol (0.15 – 2%) and are high in sucrose (>30%). Dietary palmitate and cholesterol have both previously been associated with the progression from simple steatosis to NASH.

    Examples:

     

    Research use:

    These diets can induce obesity, metabolic syndrome, and simple steatosis within nine weeks of feeding. Increased hepatic inflammation has been observed after 12 weeks of feeding. NASH typically requires longer feeding with fibrosis developing within nine months and late stage fibrosis including hepatic ballooning occurring after 14 – 20 months of feeding. Increasing dietary sucrose (~41%) and cholesterol (~1.25%) accelerates the NASH phenotype with steatosis, inflammation and hepatocyte ballooning observed within 12 weeks. In addition to feeding a high fat diet, providing a glucose/fructose mixture in the drinking water may further promote NASH development.

    Select References:

    Charlton, M., et al., Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G825-34. www.ncbi.nlm.nih.gov/pubmed/21836057

    Gores, G., Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A, Masuoko H. Am J Physiol Gastrointest Liver Physiol, 2015. 308: p. G159. ajpgi.physiology.org/content/308/2/G159

    Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44. www.ncbi.nlm.nih.gov/pubmed/19119140

    Ioannou, G.N., et al., Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J Lipid Res, 2009. 54(5): p. 1326-34. www.ncbi.nlm.nih.gov/pubmed/23417738

    Alkhouri, N., et al., Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem, 2010. 285(5): p. 3428-38. www.ncbi.nlm.nih.gov/pubmed/19940134 

    Dixon, L.J., et al., Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One, 2013. 8(2): p. e56100. www.ncbi.nlm.nih.gov/pubmed/23409132 

    DeLeve, L.D., et al., Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol, 2008. 173(4): p. 993-1001. www.ncbi.nlm.nih.gov/pubmed/18772330 

    VanSaun, M.N., et al., High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 2009. 175(1): p. 355-64. www.ncbi.nlm.nih.gov/pubmed/19541928 

    Asgharpour, A., et al., A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol, 2016. 65(3): p. 579-88. www.ncbi.nlm.nih.gov/pubmed/27261415 

    Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95. www.ncbi.nlm.nih.gov/pubmed/18772365 

    Tsuchida, T., et al., A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. Journal of hepatology, 2018. 69(2):385-395. www.ncbi.nlm.nih.gov/pubmed/29572095 

  • The ALIOS model: western diet with trans-fat

    The American Lifestyle-Induced Obesity Syndrome (ALIOS) model involves feeding the “American fast food” diet high in trans-fats and sugar. Dietary trans-fats from hydrogenated vegetable shortening (HVO) are associated with increased insulin resistance and hepatic inflammation in rodent NASH models. In addition to diet, a glucose/fructose solution is added to the drinking water and sedentary behavior promoted by removing the overhead cage feeders in this model.

    Examples:

     

    Research use:

    The ALIOS model develops obesity with insulin resistance, elevated ALT levels, and steatosis within 16 weeks. Increased inflammation and early development of fibrosis have been observed at 6 months. Severe steatosis with fibrosis and inflammation develops within 12 months of feeding with 50% of the mice reportedly developing hepatic neoplasms. Adding cholesterol (0.2%) to the American Fast Food diet may accelerate NASH phenotype development.

    Select References:

    Koppe, S.W., et al., Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol, 2009. 297(2): p. G378-84. www.ncbi.nlm.nih.gov/pubmed/19541924

    Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95. www.ncbi.nlm.nih.gov/pubmed/18772365

    Mells, J.E., et al., Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol, 2012. 302(2): p. G225-35. www.ncbi.nlm.nih.gov/pubmed/22038829

    Dowman, J.K, et al., Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. Am J Pathol, 2014. 184(5):1550-1561. www.ncbi.nlm.nih.gov/pubmed/24650559

    Mells, J.E., et al., Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem, 2014. 26(3): p. 285-92. www.ncbi.nlm.nih.gov/pubmed/25577467

  • FPC diet: fructose, palmitate, cholesterol and trans-fat diet

    The Fructose, Palmitate, Cholesterol and Trans-Fat (FPC) diet is a recent NASH diet that includes Western and ALIOS model diets to achieve both metabolic and hepatic NASH features within an accelerated time frame. Key features of the FPC diet include 1) a lower Met content than typical rodent diets by decreasing total protein without supplementing sulfur amino acids; 2) choline supplementation is lower than typical but is not considered deficient; 3) high in sucrose (~34% by weight); 4) 1.25% cholesterol; 5) 52% kcal from fat with fat sources including milkfat fat, palmitic acid and hydrogenated vegetable shortening to provide trans-fats. Like the ALIOS model, the FPC model also provides a glucose/fructose solution to the drinking water.

    Examples:

    • TD.160785 52 kcal/Fat Diet (C16:0, HVO, AMF, Choline/Met)

     

    Research use:

    Male C57BL/6J mice fed the FPC diet and provided a glucose/fructose drinking solution developed insulin resistance and NAFLD with inflammation, hepatocyte death, and fibrosis within 16 weeks.

    Select References:

    Wang, X., et al., Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis. Cell Metab, 2016. 24(6): p. 848-62. www.ncbi.nlm.nih.gov/pubmed/28068223

    Zhu, C., et al., Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Sci Transl Med, 2018. 10(468). www.ncbi.nlm.nih.gov/pubmed/30463916 

  • High fat diets

    Common diets to induce obesity (DIO) can be fed to induce uncomplicated NAFLD. These high fat diets typically contain 40–60% kcal from fat without supplemented cholesterol or cholate. Simple sugars such as sucrose or fructose can also be supplemented via diet or water to progress the fatty liver phenotype. Diets can be in pellet or powder/dough form depending on the formula. Some models require limited physical activity and in those cases diets can be fed inside the cage. For more information see our Diet Induced Obesity page.

    Examples:

     

    Research use:

    In susceptible rodent models, high fat diets are commonly used to induce NAFLD with obesity and insulin resistance common metabolic features associated with NASH in humans. However, the degree of NASH pathology (steatosis, inflammation, and fibrosis) is limited or mild and varies depending on the animal model, length of feeding, and dietary components.

  • Diets to induce severe hepatic NAFLD/NASH without obesity or metabolic

  • Atherogenic diets high in fat, cholesterol, and cholate

    Originally formulated to induce mild atherosclerosis in wild-type rodents, high fat diets containing added cholesterol (1 – 1.25%) and cholate (0.5% as sodium cholate or cholic acid) have also been useful in inducing NASH. This diet option includes purified “Western” style diets with increased cholesterol and cholate and also hybrid diets. Hybrid diets were originally developed by Beverly Paigen and colleagues by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate) resulting in a diet containing ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate. Although a less refined approach, the hybrid diet is associated with increased gallstone formation and liver damage as compared to similar purified diets.

    Examples:

     

    Research use:

    Atherogenic diets are able to induce varied degrees of NASH with increased hepatic inflammation with early fibrosis observed after ten weeks of feeding. However, the metabolic profile typical in human NASH (obesity with insulin resistance) is not recapitulated in this model with animals typically maintaining similar body weights as control fed groups without the development of metabolic syndrome.

    Select References:

    Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69. www.ncbi.nlm.nih.gov/pubmed/2380634

    Kamari, Y., et al., Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. J Hepatol, 2011. 55(5): p. 1086-94. www.ncbi.nlm.nih.gov/pubmed/21354232

    Kim, D.G., et al., Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model. J Neuroinflammation, 2016. 13: p. 1.
    www.ncbi.nlm.nih.gov/pubmed/26728181

    Madrigal-Perez, V.M., et al., Preclinical analysis of nonsteroidal anti-inflammatory drug usefulness for the simultaneous prevention of steatohepatitis, atherosclerosis and hyperlipidemia. Int J Clin Exp Med, 2015. 8(12): p. 22477-83. www.ncbi.nlm.nih.gov/pubmed/26885230

    Savransky, V., et al., Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. Am J Physiol Gastrointest Liver Physiol, 2007. 293(4): p. G871-7. www.ncbi.nlm.nih.gov/pubmed/17690174 

  • Methionine/choline deficient (MCD) diets

    Methionine and choline deficient (MCD) diets are amino acid defined rodent diets deficient in methionine and choline, high in sucrose (>40% by weight) with ~10% corn oil by weight. Methionine and choline deficiency decreases fat oxidation and export of fat from the liver. Dietary sucrose is necessary for hepatic lipid accumulation and oxidation. The polyunsaturated fat in corn oil promotes hepatic lipid oxidation.

    Example:

     

    Control:

     

    Research use:

    Steatosis, increased serum alanine aminotransferase (ALT), inflammation, and hepatic fat oxidation has been observed within three weeks of feeding the MCD diet with fibrosis development after six weeks. This dietary model does not produce metabolic syndrome (an aspect of NASH in human models) and progressive weight loss (up to 40%) is associated with the MCD diet feeding.

    Select References:

    Pickens, M.K., et al., Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis. J Lipid Res, 2009. 50(10):2072-82. www.ncbi.nlm.nih.gov/pubmed/19295183

    Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44. www.ncbi.nlm.nih.gov/pubmed/19119140

    Lee, G.S., et al., Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. J Lipid Res, 2007. 48(8): p. 1885-96. www.ncbi.nlm.nih.gov/pubmed/17526933

    Vetelainen, R., A. van Vliet, and T.M. van Gulik, Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model. J Gastroenterol Hepatol, 2007. 22(9): p. 1526-33. www.ncbi.nlm.nih.gov/pubmed/17716355

    Leclercq, I.A., et al., Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest, 2007. 87(1): p. 56-65. www.ncbi.nlm.nih.gov/pubmed/17075577

    Kashireddy, P.R. and M.S. Rao, Sex differences in choline-deficient diet-induced steatohepatitis in mice. Exp Biol Med (Maywood), 2004. 229(2): p. 158-62. www.ncbi.nlm.nih.gov/pubmed/14734794

    Dixon, L.J., et al., Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest, 2012. 92(5): p. 713-23. www.ncbi.nlm.nih.gov/pubmed/22411067

  • Emerging NASH models

    Dietary models of NAFLD/NASH continue to evolve with the goal of more accurately recapitulating both the metabolic and hepatic symptoms of human disease. Commonly researchers are studying the synergistic effects of various NASH dietary features to accelerate progression of the model and severity of liver disease.

    A Teklad nutritionist can work with you to formulate new diets in order to investigate novel dietary models of NAFLD/NASH. Contact a nutritionist at askanutritionist@envigo.com for a diet consultation.

  • Control diets

    The choice of control diet is dependent on the specific research goal. Many researchers choose to compare their NAFLD/NASH diet-fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diet or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens).

    Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component. In some cases, such as those studies feeding amino acid defined diets like the MCD model, a matched control diet is recommended given the very different formulations and protein sources of grain-based diets.

    When making inferences about specific nutrients within the diet an ingredient matched, low fat control diet may be necessary. There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined and digestible) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible).

    A very basic purified control diet would be AIN-93M TD.94048 or AIN-93G TD.94045 . AIN-93 diets have a moderate amount of sucrose at ~10% with fat from soybean oil providing a healthy fatty acid profile. Learn more about AIN diet formulas.

    Contact a nutritionist for an additional information and control diet recommendations.

Need more information? A Teklad nutritionist will work with you to determine if existing diets will meet your needs or formulate new diets to help you investigate novel dietary models of NAFLD/NASH. Contact us for a diet consultation.

Harlan Teklad动物饲料Mineral adjusted diets

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Mineral adjusted diets

Mineral adjusted diets

A few mineral adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the mineral profile of a diet. Read below for more information.

Formula examples:

  • TD.80396       Iron deficient diet
  • TD.85419       Zinc deficient diet
  • TD.88239       Potassium deficient diet
  • TD.95027       Low calcium diet (0.4% P)
  • TD.96348       Diet (20% lactose, 2% Ca, 1.25% P)
  • TD.92163       Selenium deficient diet
  • TD.95125       Iodine deficient (0.15% PTU)

Unique protein ingredients may be necessary to minimize background levels of certain minerals. Other steps taken to minimize background mineral contamination include the use of reagent grade minerals when necessary or omission of certain ingredients. Specialized mineral premixes may be used in these diets, or minerals are added individually to the diet in order to control the level of specific minerals.

With the exception of sodium, it is necessary to use refined ingredients to achieve the lowest possible levels of minerals in a diet.

From this mineral deficient base, various levels of minerals can be added back. Some formulas adjust multiple minerals, and other related nutrients.

Contact us to discuss other possibilities for the minerals listed above, and for those minerals not listed here.

Harlan Teklad动物饲料Quality assurance

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Quality assurance

Running an effective research study requires reliable products and processes.

Quality assurance

At Envigo, our quality assurance team is an integral part of delivering the consistent research models and services that you expect for your program.

Our curriculum ensures compliance with our policies as well as requirements set by AAALAC, IACUC and the USDA. To maintain our high standards, our quality assurance team is comprised of quality professionals with relevant industry certifications and credentials. In order to support our core value of animal welfare, and to optimize consistent, correct, and reliable research models for you, the provision of quality services within Research Models Services (RMS) is implemented within a framework that is closely aligned with the international standard, ISO 9001:2015.

Our quality assurance services include:

  • Core SOPs and document lifecycle control
  • Development of internal quality management systems, such as robust deviation and change management program
  • Continuous process improvement initiatives
  • Preventive controls including auditing services
  • Accurate data analytics through the use of TrackWise®, a leading complaint management system

Through the effective application of a risk-based quality management system and an internal continuous improvement process, we proactively monitor, track and remediate issues as they arise. This strategic method allows us to quickly take action and improve operational performance. Externally, we work with global regulatory authorities to verify that our operations, facilities and processes meet or exceed local and international standards.

With best practices identified and replicated across our global sites, we can offer high-quality research models and services that uphold our stringent quality assurance standards and our brand promise to enable your ongoing success.

Harlan Teklad动物饲料Corporate social responsibility

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Corporate social responsibility

Corporate social responsibility

Corporate social responsibility (CSR) has always been part of the way we’ve done business — it’s what we do and how we do it.

Our vision is ‘Working together to build a healthier and safer world.’ We work with our customers in the knowledge that the research they conduct, and the products we help them develop, have the potential to enhance life. Our role is to deliver the highest levels of ethical and scientific standards, customer service and compliance.

Our commitment to acting responsibly in achieving this vision is strengthened by our company values:

  • Doing our best work, together, every day
  • Caring about each other, our animals and the environment
  • Being honest and respectful
  • Always learning, challenging and improving

 

These values provide guidance and perspective in the way we manage our business, enabling us to act as a responsible company and ensuring that decisions take account of ethical, social and environmental concerns.

This commitment to CSR helps us to serve our customers, operate efficiently and sustainably, gain the trust of our stakeholders, and foster the right environment to further develop our business.

Our CSR is focused on the following areas:

  • Labour and human rights
  • Combating bribery and anti-competitiveness
  • Data protection
  • Animal welfare
  • Environment
  • Compliance and accreditation

 

At Envigo we are committed to corporate social responsibility.

More CSR information

  • Global code of conduct
  • Envigo integrity line
  • Anti-bribery and corruption
  • Data protection
  • Equal opportunities
  • Ethical and responsible standards
  • Privacy
  • Quality policy
  • Supplier code of conduct
  • Gender pay gap reporting in the UK

Harlan Teklad动物饲料NaCl adjusted (natural ingredient)

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NaCl adjusted (natural ingredient)

NaCl adjusted (natural ingredient)

The sodium content of natural ingredients such as corn, wheat, and soybean meal is low. Thus, these ingredients can be used to create a base diet that is sodium deficient. To this base diet, various amounts of sodium chloride salt (NaCl) can be added, and other ingredients adjusted slightly to maintain a relatively constant nutrient profile (with the exception of sodium and chloride).

Below are examples from a popular series of adjusted NaCl diets. Contact us for more information.

Formula examples
Added NaCl (%) Approx. Na (%) no dye red* dye orange* dye blue* dye
Na deficient 0.01-0.02 TD.90228 TD.08290    
Possible control diets: 0.05% Na (0.1% NaCl) meets est. minimum Na requirement. Typical rodent diets contain 0.2%-0.4% Na (~0.5-1% NaCl).
0.1 0.05 TD.94268   TD.07334  
0.49 0.2 TD.96208   TD.110765  
1 0.4 TD.90229      
Diets for studies that look at effects of excess sodium consumption in rodents.
2 0.8 TD.95078   TD.130345  
4 1.6 TD.92034 TD.110078   TD.03095
8 3.2 TD.92012 TD.03142    

* When added to natural ingredient diets, these water soluble food dyes offer a slight color tint. More intense color can be achieved at higher inclusion rates.

Ask a nutritionist about additional salt concentrations or color options.

These diets are grain-based, with no animal derived ingredients, and have a background sodium content of approx. 0.01-0.02% and a background chloride content of approx. 0.06-0.07%. The selected nutrient content of the diets are as follows: approximately 19% protein, 5% fat, 3% crude fiber, 0.86% Ca, 0.64% P, 0.72% K, and 0.15% Mg.

NaCl adjusted diets are often fed to dahl salt-sensitive/resistant (rapp) inbred rats. These rats are maintained on Teklad traditional diet 7034 (0.12% NaCl) within maximum security production facilities.

For additional formulas of this nature, or for a purified sodium adjusted diet, please email us at askanutritionist@envigo.com.

Harlan Teklad动物饲料Carbohydrate adjusted

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Carbohydrate adjusted

Carbohydrate adjusted

A few carbohydrate adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the carbohydrate profile of a diet.  

Formula examples:

  • TD.89247       60% Fructose diet 
  • TD.86489       Diet with adjusted sucrose/cornstarch
  • TD.96348       Diet (20% lactose, 2% Ca, 1.25% P)
  • TD.98090       70% Carbohydrate diet
  • TD.96355       Ketogenic diet (almost no carbohydrate)

 

Carbohydrates often make up the majority (by weight and % kcal) of custom research diets, with the exception of higher fat diets. Commonly used carbohydrate sources include sucrose, cornstarch and maltodextrin. Other sources include fructose, dextrose (glucose), dextrin, and lactose. Maltodextrin is enzymatically derived from cornstarch to have shorter glucose polymers and is helpful in pelleting high fat diets and in diets where cornstarch exceeds sucrose.

Sucrose is a part of most formulas, often making up 10% of the diet or more. This likely adds to the palatability of the diet. The carbohydrate profile of a diet can be manipulated, although some mixtures may not pellet. There are also diets with very little carbohydrate, thus containing high amounts of fat and/or protein.

Cellulose (fiber) is part of many formulas and while not required by rodents, is considered beneficial. It can also be used to make formulas with differing macronutrient profiles isocaloric.

Harlan Teklad动物饲料Protein adjusted diets

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Protein adjusted diets

Protein adjusted diets

A few protein adjusted formulas are shown below. Please contact us for additional formulas of this nature or for more information about altering the protein type or content of a diet.

Formula examples:

These diet examples are from a series of diets with the following features: casein-based, isocaloric (3.8 kcal/g) and matched for fat (5.5%), calcium (0.7%), and phosphorus (0.54%). There are other diets available from this series of diets, as well as other unique protein adjusted diets.

Casein is the most widely used refined protein source, but it is also possible to use other refined protein sources, such as “vitamin-free” test casein (alcohol extracted), lactalbumin, isolated soy protein, and egg white solids. These particular protein sources are usually used to achieve a specific research objective, rather than for routine use. For instance, vitamin-free test casein is most appropriately used in vitamin deficient diets, and egg white solids is most suitable for zinc or biotin deficient diets.

Adjusted protein diets usually range from “protein-free” (trace) to 60% protein, depending on the research.

Harlan Teklad动物饲料Basal mixes

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Basal mixes

Basal mixes

You may want to add some specific ingredients in your own facility. In that case, Envigo provides basal mixes that are, by design, a starting point for additional inclusions. When you choose a basal mix diet, you simply add any ingredient(s) in a specific proportion that your require. The nutrient levels in our basal mix are adjusted to account for the dilution of the added ingredient(s), so that the final complete diet contains the desired nutrient levels.

  • TD.00235       Basal mix (93%); AIN-93G without fat
  • TD.88232       Basal mix (without 20% Oil)

Here are some examples of how a basal mix could be helpful to you:

  • Leave all or a portion of the fat source out. The end user can add various fats and make multiple diets from one basal mix
  • Make fresh diet as needed for an unstable, hazardous, or limited supply ingredient
  • Add a different vitamin or mineral mix to the same basal mix to create a series of vitamin or mineral adjusted diets

If proper mixing equipment is available, and you have the capability to feed powder diet, basal mixes offer flexibility and economy.

Harlan Teklad动物饲料Rabbit, swine and other species diets

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Rabbit, swine and other species

Rabbit, swine and other species diets

The most common custom rabbit diets are those with a standard diet base and added cholesterol. Typically, the added cholesterol ranges from 0.25% to two percent. Additional fat can also be a feature of these formulas. To preserve pellet quality we recommend no more than six percent additional fat. Added fat is most often supplied as peanut oil, corn oil, coconut oil, or a combination. We recommend the Teklad base diets 2030 or 2031.

Rabbits do not readily consume purified diet. When specific nutrient manipulations are necessary, hybrid diets or at least some alfalfa meal inclusion is recommended. Contact us for formula examples or to discuss your specific needs.

Most often, customized diets for swine feature natural ingredients with added fat and cholesterol. Here are three variations on this theme:

  • TD.92033 Swine diet (15% lard, 1.2% cholesterol)
  • TD.92052 Swine diet (15% lard, 1.5% cholesterol)
  • TD.93296 Swine diet (15% lard, two perecent cholesterol)

We recommend these diets in meal/powder form, as pellets are not very durable. Other natural ingredient and purified diets with various nutrient manipulations are available. Contact us for further information.

The most common custom Guinea pig diets are those with a standard diet base (such as Teklad 2040 or 2041) and added cholesterol.

Guinea pigs do not readily consume purified diets, so when specific nutrient manipulations are necessary, hybrid diets (mixture of refined and natural ingredients) are recommended. At the very least it is advisable to retain some alfalfa meal in the diet. Contact us for further information.

Most times, diets that are developed for mice and rats are suitable for hamsters and gerbils, and vice versa. We may advise increasing specific nutrients in a purified diet for hamsters and gerbils. Contact us for further information.

Depending on the focus of your research, customized diet for non-human primates can contain natural ingredients, refined ingredients, or a mixture of both. Custom diets for primates often feature adjustments in fat type, fat level, and cholesterol. Contact us for further information.

Harlan Teklad动物饲料Tamoxifen diets

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Tamoxifen diets

Tamoxifen diets

Diets with tamoxifen activate CreER

Several references cite use of tamoxifen-containing diets for models with Cre under the control of a mutated estrogen receptor. Envigo Teklad diets makes a variety of tamoxifen-containing diets customized to meet your research needs. We also make a variety of doxycycline-containing diets for tet regulated systems. If you have any questions, don’t hesitate to consult a nutritionist.

Teklad stocks tamoxifen and tamoxifen citrate

Tamoxifen is added to the diet as a tamoxifen-sucrose mixture. Users are encouraged to use the stocked supply. However, Teklad will continue to work with customer prepared mixes. If you choose this option, please consult a nutritionist for additional information about preparing and sending the mixture.

Users are encouraged to select from the stocked options below supply readily available to ship within days.

Teklad offers diet with USP grade tamoxifen and tamoxifen citrate

Tamoxifen
mg per kg diet
Daily tamoxifen
mg per kg body weight1
Diet code (Teklad supplied tamoxifen) Diet code (Teklad supplied tamoxifen)
Natural colored Red
250 40 TD.130855 TD.130856
500 80 TD.130857 TD.130858
400 citrate2 40 TD.130859 TD.130860 3

1 Assumes 20-25 g body weight and three-four g intake
2 Tamoxifen citrate is 66% tamoxifen
3 Referred to as TAM400/CreER in Europe (TD.55125 )

Please add 5-10 day lead time for irradiated diets; minimum 3 kg orders are required for stocked and customized items.

These diets all have tamoxifen premixed with ~five percent sucrose as a palatability enhancer; however, feed aversion may still occur. If intake is a problem, see below for advice.

Teklad Global 2016 — base diet in these examples — is only one of several minimal phytoestrogen diets Teklad produces. Consult a nutritionist about use of other base diets.

Key planning information

  • Minimum order quantity is three kg, sufficient for feeding ~20 mice for one month
  • Store diet refrigerated and plan to use within six months
  • Typical lead time is two weeks (four weeks if irradiated)
  • Irradiation (optional) minimal dose of 20 kGy (Must be requested at time of order)
  • To place an order: contact Teklad Customer Service at 800.483.5523 or initiate order online

Mice need time to adjust

Plan for:

  • Initial reduction in food intake and weight loss
  • Daily observation of animal tolerance — consult your IACUC for monitoring metrics
  • Intervene when necessary

Other researchers have the following advice

If intake seems to be a problem:

  • Determine if a lower dose is effective for your model by conducting a tamoxifen dose feeding trial
  • Gradually acclimate mice by mixing tamoxifen-containing pellets with regular feed pellets
  • Wet the food, then place in a dish inside the cage (requires daily replacement)
  • Feed tamoxifen diet on weekdays, regular diet on weekends
  • Alternate weeks (two weeks on tamoxifen diet, one week off) for longer treatments

Safe handling of tamoxifen diets

  • Tamoxifen is a selective estrogen receptor modulator (SERM) meaning it can repress actions of estrogen or have pro-estrogen effects
  • Usual dose for therapeutic effects in humans is 20 mg/day. Tamoxifen diets for rodents typically contain ~one to two mg/pellet
  • Accidental tamoxifen exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
  • Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of tamoxifen containing diets.

Key points from literature

  • Length of treatment varies from one to two weeks1,2,5,6,7,8 to one to two months3,4,8
  • Pure tamoxifen1,5,8 and tamoxifen citrate1,2,3,4,6,7 are both effective
    Usual tamoxifen doses are ~40-80 mg per kg body weight per day
  • Typical inclusion for pure tamoxifen is 250 mg8 or 500 mg1,5 and for tamoxifen citrate is 400 mg per kg diet1,2,3,4,6,7
  • Initial weight loss of ten % is reported1,2,4,7,8, associated with reduced food intake2
  • Subsequent recovery of body weight after returning to regular diet may be compromised by gene inactivation2,7

Selected tamoxifen references

1 Andersson KB, Winer LH, Mork HK, Molkentin JD, Jaisser F. 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Res 19:715-725.

2 Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci USA 107:16320-16324.

3 Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6:e21055.

4 Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M. 2007. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45:11-16.

5 Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15.

6 Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F. 2009. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. PCirc Res 106:559-572.

7 Miro-Murillo M, Elorza A, Soro-Arnaiz I, Albacete-Albacete L, Ordonez A, Balsa E, Vara-Vega A, Vazquez S, Fuertes E, Fernandez-Criado C, Landazuri MO, Aragones J. 2011. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS One 6:e22589.

8 Welle S, Burgess K, Thornton CA, Tawil R. 2009. Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab.Oct;297(4):E935-40.

If you have any questions regarding tamoxifen diets, please don’t hesitate to contact a nutritionist at askanutritionist@envigo.com.